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Synthesis and evaluation of novel isothiocyanates
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Synthesis and evaluation of novel isothiocyanates
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Description
Title
Synthesis
and
evaluation
of
novel
isothiocyanates
Author(s)
Tornberg
,
Elle
H
.
Co-author(s)
Lensing
,
Cody
J.
;
Mays
,
Jared
R
.
Abstract
Evidence
suggests
isothiocyanates
(ITCs)
are
responsible
for the
chemoprevention
associated
with
diets
rich
in
cruciferous
vegetables
.
Non-natural
ITCs
have
previously
demonstrated
enhanced
antiproliferation
activity
versus
the
natural
ITC
L-sulforaphane
. To
elucidate
structure-activity
trends
, a
panel
of
novel
ITCs
have been
synthesized
and
tested
against
MCF-7
human
breast
cancer
cells
.
Preliminary
results
have
identified
several
key
structure-activity
relationships
that will be
useful
in
developing
improved
agents
.
Subject (LC)
Breast--Cancer--Molecular aspects
Breast--Cancer--Chemoprevention
Subject (FAST)
Breast--Cancer--Molecular aspects
Breast--Cancer--Chemoprevention
Research affiliation
BRIN (Biomedical Research Infrastructure Network)
Collection
Augustana Student Research
Date
2012
Rights
This image may not be reproduced without the express written consent of Augustana University, Sioux Falls, South Dakota, USA.
Type
Poster
Medium
Image
Format - Digital
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