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Synthesis and evaluation of novel isothiocyanates

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Synthesis and evaluation of novel isothiocyanates

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Title	Synthesis and evaluation of novel isothiocyanates
Author(s)	Tornberg, Elle H.
Co-author(s)	Lensing, Cody J.; Mays, Jared R.
Abstract	Evidence suggests isothiocyanates (ITCs) are responsible for the chemoprevention associated with diets rich in cruciferous vegetables. Non-natural ITCs have previously demonstrated enhanced antiproliferation activity versus the natural ITC L-sulforaphane. To elucidate structure-activity trends, a panel of novel ITCs have been synthesized and tested against MCF-7 human breast cancer cells. Preliminary results have identified several key structure-activity relationships that will be useful in developing improved agents.
Subject (LC)	Breast--Cancer--Molecular aspects Breast--Cancer--Chemoprevention
Subject (FAST)	Breast--Cancer--Molecular aspects Breast--Cancer--Chemoprevention
Research affiliation	BRIN (Biomedical Research Infrastructure Network)
Collection	Augustana Student Research
Date	2012
Rights	This image may not be reproduced without the express written consent of Augustana University, Sioux Falls, South Dakota, USA.
Type	Poster
Medium	Image
Format - Digital	pdf